徐磊导师简介

个人简介：

徐磊，女，1991年01月出生，毕业于沈阳药科大学。博士，讲师，山西中医药大学硕士生导师。先后主持科研项目8项，发表论文11篇，其中中文核心（或SCI）论文10篇。

研究学科（领域）：中医基础理论

研究方向：中医药防治神经退行性疾病的研究

在研项目：（参考以下格式）

1.徐磊，山西省应用基础研究计划项目：基于外泌体miRNA-146a介导的神经炎症探讨人参二醇对PD保护作用的生物学机制，项目编号：202203021222279，执行年限：2023.03-2026.03，项目经费：5万元

2.徐磊，山西省中医药管理局：五子衍宗丸调控外泌体 miRNA 干预帕金森的机制，项目编号：2023ZYYC063，执行年限：2022.11-2025.11，项目经费：2万元

3.徐磊，山西中医药大学博士科研启动基金项目：五子衍宗丸调控帕金森病神经炎症机制及物质基础，项目编号：2023BK04，执行年限：2023.06-2026.05，项目经费：25万元

代表性成果：

1. Lei Xu, Zhongjin Zhang, Ziqi Feng, Sixiang Niu, Shengnan Xiao, Zhi Chai. Study on the anti-Parkinson's disease activity mechanism and preparation of panaxadiol. Phytomedicine. 2025 Jan;136:156296.

2. Lei Xu, Shengnan Xiao, Zhi Chai, Yuqing Zhao. Study of novel ginsenoside metabolites targeting HSP70 as anti-prostate cancer drugs. Bioorganic Chemistry. 2024 Mar;144:107131.

3. Lei Xu, Xiaomin Li, Lizhen Lin, Xinliang Mao, Jung Joon Lee, Jianwen Ye, Hua Jiang, Guangyue Su, Yuqing Zhao. Preparation process, composition and activity evaluation of Ginseng-Sea buckthorn functional drink, Journal of Functional Foods, Volume 110, 2023, 105866.

4. Lei Xu, Shengnan Xiao, Jung Joon Lee, Xiaofei Li, Yuqing Zhao. Gender-related differences in tissue distribution, excretion, and metabolism studies of Panaxadiol in rats and anti-inflammatory study, Journal of Agricultural and Food Chemistry, 2022, 70, 28, 8672–8679.

5. Lei Xu, Shengnan Xiao, Jung Joon Lee, Hua Jiang, Xiaofei Li, Xiaoshu Zhang, Yuqing Zhao. In vivo metabolites of Panaxadiol inhibit HepG-2 cell proliferation by inducing G1 arrest and ROS mediated apoptosis. Journal of Agricultural and Food Chemistry , 2022, 70, 37, 11560-11571.

6. Lei Xu, Xiaoshu Zhang, Shengnan Xiao, Xiaofei Li, Hua Jiang, Ziyi Wang, Baoshan Sun, Yuqing Zhao. Panaxadiol as a major metabolite of AD-1 can significantly inhibit the proliferation and migration of breast cancer cells: In vitro and in vivo study, Bioorganic Chemistry, 2021, 116, 105392.

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