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孟祥龙

发布者： [发表时间]：2024-11-26 [来源]： [浏览次数]：

孟祥龙导师简介

个人简介：

孟祥龙，男，1988年7月18日出生，毕业于Dongguk University/东国大学（韩）。博士，高级实验师，山西中医药大学硕士生导师。先后主持科研项目13项，近十年发表学术论文62篇（其中以第一/通讯作者发表SCI收录文章15篇、中文核心论文13篇）。

研究学科（领域）：中药学（中药炮制）

研究方向：中药炮制及药效物质基础研究

在研项目：

1.山西省留学人员科技活动择优资助项目（重点项目），20230034，基于PI3K/AKT/mTOR及AMPK/mTOR通路调控自噬平衡探讨当归六黄汤保护胰岛β细胞机制，2023-06至2026-05，12万元，在研，主持；

2.省筹资金资助归国留学人员科研项目，2023-156，熟地黄中5-HMF和异毛蕊花糖苷通过激活自噬以抗凋亡发挥对胰岛β细胞的保护作用及机制研究，2023-07至2026-06，6万元，在研，主持；

3.中医药管理局科研课题项目，2023ZYYA2012，基于多组学的当归六黄汤治疗T2DM小鼠物质基础及作用机制研究，2023-06至2026-05，5万元，在研，主持；

4.山西省科学技术厅, 山西省基础研究计划（自由探索类）青年项目, 20210302124694, 生、熟地黄通过肠道菌群调控AMPK通路影响T2DM胰岛素抵抗的作用差异性研究, 2022-01 至 2024-12，4万元, 在研, 主持；

5.山西中医药大学博士科研启动基金项目，2023BK38，基于PI3K/Akt/mTOR通路探究生地黄通过激活自噬和抗凋亡发挥对胰岛β细胞的保护作用及机制，2023-05至2026-06，10万元, 在研, 主持；

代表性成果：

  1. Meng X, Liu X, Tan J, et al. From Xiaoke to diabetes mellitus: a review of the research progress in traditional Chinese medicine for diabetes mellitus treatment. Chin Med. 2023;18(1):75. Published 2023 Jun 22. doi:10.1186/s13020-023-00783-z

  2. Meng X, Yan J, Ma J, et al. Effects of Jowiseungki-tang on high fat diet-induced obesity in mice and functional analysis on network pharmacology and metabolomics analysis. J Ethnopharmacol. 2022;283:114700. doi:10.1016/j.jep.2021.114700

  3. Meng X, Zhang X, Su X, et al. Daphnes Cortex and its licorice-processed products suppress inflammation via the TLR4/NF-κB/NLRP3 signaling pathway and regulation of the metabolic profile in the treatment of rheumatoid arthritis. J Ethnopharmacol. 2022;283:114657. doi:10.1016/j.jep.2021.114657

  4. Meng X, Lyu C, Ma J, et al. Metabolomics and Network Pharmacology-Based Investigation into the Mechanisms Underlying the Therapeutic Effect of a New Chinese Traditional Medicine (Cui Nai Ling) on Bromocriptine-Induced Hypogalactia. Evid Based Complement Alternat Med. 2021;2021:8857449. Published 2021 Jun 16. doi:10.1155/2021/8857449

  5. Meng X; Ma J; Kang AN; Kang SY; Jung HW; Park YK*; A Novel Approach Based on Metabolomics Coupled With Intestinal Flora Analysis and Network Pharmacology to Explain the Mechanisms of Action of Bekhogainsam Decoction in the Improvement of Symptoms of Streptozotocin-Induced Diabetic Nephropathy in Mice, Front Pharmacol, 2020, 11:633. Published 2020 May 21. doi:10.3389/fphar.2020.00633.

  6. Xianglong Meng; Junnan Ma; Seok Yong Kang; Hyo Won Jung; Yong-Ki Park*; Jowiseungki decoction affects diabetic nephropathy in mice through renal injury inhibition as evidenced by network pharmacology and gut microbiota analyses, Chin Med 15, 24 (2020). https://doi.org/10.1186/s13020-020-00306-0.

  7. Xiang-long Meng; Bo Wang; Chen-zi Lv; Cong Hu; Mei-jing He; Shuo-sheng Zhang*; Quantification of Chinese yam processing methods based on pyrolysis characteristics and its relation to Maillard reaction, Chinese Herbal Medicines (CHM), 2020, (1):56-66.

  8. Jing-Ning Yan; Cong Hu; Xiang-Long Meng*; East to west: research progress in traditional Chinese medicine for antiaging strategies,  Traditional Medicine Research , 2020, 5 (5): 305-321. doi: 10.12032/TMR20200121155.

  9. Bao-Tong Li, Yi Zhou, Xiao-Juan Su, Xiang-Long Meng*. Is “Pangolin (Manis Squama) is not used in medicine＂ an improvement in the protection of precious and rare species or an improvement in the safety of using medicine?. Traditional Medicine Research 2020, 0 (0): 0. doi: 10.12032/TMR20201001201.

  10. Xiang-Long Meng, Bo Wang, Xiao-Yan Zhang, et al. The dynamic changes and mechanisms of Rehmanniae radix processing based on Maillard reaction. Traditional Medicine Research 2020, 0 (0): . doi: 10.12032/TMR20200603188.

  11. Xiang-Long Meng, Xiao-Yan Zhang, Cong Hu, et al . The riddles of number nine in Chinese medicine processing method. Traditional Medicine Research 2020, 0 (0): . doi: 10.12032/TMR20200603187.

  12. Xiang-Long Meng, Yong-Lin Liang, Chen-Zi Lyu, et al . Effects of processing technology on essential oil and pharmacological action of frankincense. Traditional Medicine Research 2020, 0 (0): . doi: 10.12032/TMR20200831196.

  13. Liu X, Meng X(并列一作), Su X, et al. The mechanism of ginger and its processed products in the treatment of estradiol valerate coupled with oxytocin-induced dysmenorrhea in mice via regulating the TRP ion channel-mediated ERK1/2/NF-κB signaling pathway. Food Funct. 2022;13(21):11236-11248. Published 2022 Oct 31. doi:10.1039/d2fo01845d

  14. 闫京宁,刘晓琴,孟祥龙*等.生、熟地黄对高脂饲料并链脲佐菌素诱导的2型糖尿病小鼠胰脏蛋白质组学与自噬差异性干预研究[J].中国中药杂志,2023,48(06):1535-1545.DOI:10.19540/j.cnki.cjcmm.20220901.301.

  15. 孟祥龙,刘晓琴,宁晨旭等.生、熟地黄通过AMPK介导NF-κB/NLRP3信号通路改善高脂饲料并链脲佐菌素诱导的糖尿病小鼠的作用机制差异性研究[J].中国中药杂志,2021,46(21):5627-5640.DOI:10.19540/j.cnki.cjcmm.20210323.302.

  16. 孟祥龙; 王勃; 胡聪; 吕辰子; 张晓燕; 张朔生*; 基于HPLC-MS及网络药理学探讨熟地黄炮制过程与美拉德反应的相关性, 中药材, 2020(01):61-70[2020-02-24].https://doi.org/10.13863/j.issn1001-4454.2020.01.013.

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