石新丽导师简介
个人简介：
石新丽，女，1976年3月出生，毕业于四川大学。免疫学博士，教授，博士生、硕士生导师。先后主持科研项目 项，发表论文40余篇，其中以通讯作者指导学生发表SCI论文 24篇，出版专著2部。
研究学科（领域）：
1.中医基础理论（中西医结合基础研究）
2.中医内科学（中医药防治肿瘤疾病的研究）
3.中药学（中药药理学）
研究方向：中西医结合肿瘤免疫
在研项目：
1.基于HIF-1a/SLC2A1介导的糖酵解代谢探讨YAP1促进肝癌免疫逃逸的表观遗传学机制及双氢青蒿素的调控效应（82274315），国家自然科学基金面上项目，2023/01-2026/12, 52万元，在研，主持
2.横向分部/纵向分经的腧穴效应规律及其机制研究（2022YFC3500600），1200万，国家重点研发计划“中医药现代化”重点专项2022年度项目，2023/01-2026/12，在研，参与，第6。
3.中西医结合肿瘤免疫学研究（zyytd2024021），山西省中医药管理局中医药创新团队，2024.3-2027.3，30万，主持，在研
4.中西医结合肿瘤免疫学重点研究室（zyyyjs2024035），山西省重点实验室建设项目，2024.3-2027.3，0万，主持，在研
5.中医药抗肿瘤免疫学机制研究（2023RC03），山西中医药大学高层次人才引进项目，2023.7-2028.7，300万，主持，在研
6.枸杞提高AKK菌丰度改善药物性肝损伤的机制，2023BKS29， 山西省优秀博士毕业生来晋工作奖励经费科研启动基金项目，2023.11.1-2025.10.30，10万，主持，在研
7.基于非靶向代谢组学探讨YAP1抑制马兜铃酸肝损伤的机制（2023ZYYDA2039），山西省中医药管理局科研课题重点项目，2023/08-2024/12，5万，主持，在研
代表性成果：
论文
1. Yuting Gao# , Yi Gong#, Junlan Lu, Yanguang Yang, Yuman Zhang, Yajun Xiong, Xinli Shi*，Dihydroartemisinin breaks the positive feedback loop of YAP1 and GLUT1-mediated aerobic glycolysis to boost the CD8+ effector T cells in hepatocellular carcinoma，Biochemical Pharmacology，2024, 116294.（In Press）通讯作者 中科院2区,Top期刊
2. Junlan Lu, Yuting Gao, Yi Gong, Yuan Yue, Yanguang Yang, Yajun Xiong, Yuman Zhang, Yan Xiao, Haodong Wang, Haibo Fan, Xinli Shi*，Lycium barbarum L. balanced intestinal flora with YAP1/FXR activation in drug-induced liver injury，International Immunopharmacology，2024，130 ：111762. 通讯作者 中科院2区,Top期刊，
3. Yuting Gao#, Yi Gong#, Junlan Lu#, Huiqin Hao*, Xinli Shi*, Targeting YAP1 to improve the efficacy of immune checkpoint inhibitors in liver cancer: mechanism and strategy，Frontiers in Immunology，2024，15:1377722. 通讯作者 中科院2区,Top期刊
4. Junlan Lu, Yi Gong, Yuting Gao, Yanguang Yang, Yuman Zhang, Zhiqin Zhang, Xinli Shi*, Wolfberry, Yam, and Chrysanthemum polysaccharides increased intestinal Akkermansia muciniphila abundance and hepatic YAP1 expression to alleviate DILI，FASEB Journal，2023，37(12):e23286. 通讯作者 中科院2区,Top期刊
5. Yanguang Yang#, Yuting Gao#, Yajun Xiong#, Yi Gong, Junlan Lu, Yuman Zhang, Dan Wang, Zhihan Liu, Xinli Shi*,Research progress of Warburg effect in Hepatocellular Carcinoma,Frontiers in Bioscience-Landmark, 2024, 29(5), 178. (约稿)
6. Yanguang Yang, Shenghao Li, Qing Peng, Yinglin Guo, Yuting Gao, Yi Gong, Junlan Lu, Yuman Zhang, Xinli Shi *,Human umbilical cord mesenchymal stem cells promoted tumor cell growth associated with increased interleukin-18 in hepatocellular carcinoma，Molecular Biology Reports，2024，51(1):762.通讯作者
7. Yanguang Yang, Yuting Gao, Yi Gong, Junlan Lu, Shenghao Li, Yajun Xiong, Yuman Zhang, Dan Wang, Peng Gong, Yunfeng Li *, Xinli Shi*，Dihydroartemisinin breaks the immunosuppressive tumor niche during cisplatin treatment in Hepatocellular carcinoma， Acta Histochemica，2024，126，152171. 通讯作者
8. Yu Xue#, Junlan Lu#, Yiwei Liu#, Yuting Gao, Yi Gong, Yanguang Yang, Yajun Xiong, Xinli Shi*,Dihydroartemisinin modulated arachidonic acid metabolism and mitigated liver inflammation by inhibiting the activation of 5-LOX and COX-2，Heliyon，2024，e33370. 通讯作者
9. Liyuan Hao, Yinglin Guo, Qing Peng, Zhiqin Zhang, Jingmin Ji, Yiwei Liu, Yu Xue, Caige Li, Kangning Zheng, Xinli Shi*，Dihydroartemisinin reduced lipid droplet deposition by YAP1 to promote the anti-PD-1 effect in hepatocellular carcinoma, Phytomedicine,2022,96:153913. 10.1016/j.phymed.2021.153913 0944-7113
通讯作者 中科院1区,Top期刊
10. Qing Peng#, Shenghao Li#, Xinli Shi*, Yinglin Guo, Liyuan Hao, Zhiqin Zhang, Jingmin Ji, Yanmeng Zhao, Caige Li, Yu Xue, Yiwei Liu，Dihydroartemisinin broke the tumor immunosuppressive microenvironment by inhibiting YAP1 expression to enhance anti-PD-1 efficacy, Phytotherapy Research,2023,37(5):1740-1753. DOI:10.1002/ptr.7695 通讯作者 中科院2区
11. Yinglin Guo, Qing Peng, Liyuan Hao, Jingmin Ji, Zhiqin Zhang, Yu Xue, Yiwei Liu, Yuting Gao, Caige Li, Xinli Shi*,Dihydroartemisinin promoted FXR expression independent of YAP1 in hepatocellular carcinoma,FASEB Journal, 2022, 36(6):e22361.DOI: 10.1096/fj.202200171R。published on2022.05.260892-6638
通讯作者 中科院2区,Top期刊
12. Yiwei Liu#, Yu Xue#, Zhiqin Zhang, Jingmin Ji, Caige Li, Kangning Zheng, Junlan Lu, Yuting Gao, Yi Gong, Yuman Zhang, Xinli Shi*,Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury, FASEB Journal. 2023,37(1):e22689. IF:5.834 doi: 10.1096/fj.202200945R.通讯作者 中科院2区, Top期刊
13. Kangning Zheng，Wenhan Zhou，Jingmin Ji，Yu Xue，Yiwei Liu，Caige Li，Zhiqin Zhang，Junlan Lu，Xinli Shi*，Yongmin Li*，Si-Ni-San reduces lipid droplet deposition associated with decreased YAP1 in metabolic dysfunction-associated fatty liver disease，Journal of Ethnopharmacology，2023, 305(1):116081. doi:10.1016/j.jep.2022.116081 通讯作者
14. Caige Li, Yu Xue, Yiwei Liu, Kangning Zheng, Yuting Gao, Yi Gong, Junlan Lu, Yuman Zhang, Jingmin Ji, Zhiqin Zhang, Xinli Shi1*,Hepatocyte-specific Yap1 knockout maintained the liver homestasis of lipid metabolism in mice，Diabetes, Metabolic Syndrome and Obesity，2024 Aug 27;17:3197-3214. doi: 10.2147/DMSO.S472778。
15. Yi Gong# ，Qing Peng#， Yuting Gao， Jiali Yang， Junlan Lu， Yuman Zhang，Yanguang Yang ，Hua Liang，Yuan Yue ， Xinli Shi *，Dihydroartemisinin inhibited interleukin-18 expression by decreasing YAP1 in hepatocellular carcinoma cells，Acta Histochem， 2023，125(4):152040. doi: 10.1016/j.acthis.2023.152040. 通讯作者
16. Zhiqin Zhang#, Xinli Shi*, Jingmin Ji#, Yinglin Guo, Qing Peng, Liyuan Hao, Yu Xue, Yiwei Liu, Caige Li, Junlan Lu, Kun Yu，Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy，Frontiers of Medicine，2023，17(4):729-746. 通讯作者
17. Yuting Gao#, Qing Peng#, Shenghao Li, Kangning Zheng, Yi Gong, Yu Xue, Yiwei Liu, Junlan Lu, Yuman Zhang, Xinli Shi*,YAP1 suppression inhibits autophagy and improves the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma，Experimental Cell Research, 2023, 424(1):113486. doi:10.1016/j.yexcr.2023.113486 通讯作者
18. Yuting Gao#, Yi Gong#, Yiwei Liu, Yu Xue, Kangning Zheng, Yinglin Guo, Liyuan Hao, Qing Peng, Xinli Shi*, Integrated analysis of transcriptomics and metabolomics in human hepatocellular carcinoma HepG2215 cells after YAP1 knockdown，Acta Histochemica，2023, 125（1）：151987. doi: 10.1016/j.acthis.2022.151987 通讯作者
19. Qing Peng, Liyuan Hao, Yinglin Guo, Zhiqin Zhang, Jingmin Ji, Yu Xue, Yiwei Liu, Caige Li, Junlan Lu, Xinli Shi*, Dihydroartemisinin inhibited the Warburg effect through YAP1/SLC2A1 pathway in hepatocellular carcinoma, Journal of Natural Medicines,2023,77(1):28-40.(IF:4.6) 10.1007/s11418-022-01641-2 1340-3443 通讯作者
20. Qing Peng, Liyuan Hao, Yinglin Guo, Zhiqin Zhang, Jingmin Ji, Yu Xue, Yiwei Liu, Junlan Lu, Caige Li, Xinli Shi*, Solute carrier family 2 members 1 and 2 as prognostic biomarkers in hepatocellular carcinoma associated with immune infiltration. World J Clin Cases, 2022,10(13): 3989-4019.
doi: 10.12998/wjcc.v10.i13.3989 2307-8960 通讯作者 (约稿)
21. Jingmin Ji#, Zhiqin Zhang#, Qing Peng, Liyuan Hao, Yinglin Guo, Yu Xue, Yiwei Liu, Caige Li, Xinli Shi*，The Effects of Qinghao-Kushen and Its Active Compounds on the Biological Characteristics of Liver Cancer Cells，Evid Based Complement Alternat Med，2022:8763510.（IF：2.65） doi: 10.1155/2022/8763510. 1741-427X 通讯作者
22. Jingmin Ji, Zhiqin Zhang, Hongyue Gao, Wenhan Zhou, Yongmin Li , Xinli Shi*, Modulation of Oral Microflora during Helicobacter Pylori Eradication, J Coll Physicians Surg Pak, 2022, 32(03):308-312. doi: 10.29271/jcpsp.2022.03.308. 1022-386X 通讯作者
23. Liyuan Hao, Shenghao Li, Qing Peng, Yinglin Guo, Jingmin Ji, Zhiqin Zhang, Yu Xue, Yiwei Liu, Xinli Shi*, Anti-malarial drug dihydroartemisinin downregulates the expression levels of CDK1 and CCNB1 in liver cancer, Oncol Lett, 2021,22(3):653. 通讯作者
24. Shenghao Li#, Jingmin Ji#, Zhiqin Zhang, Qing Peng, Liyuan Hao, Yinglin Guo, Wenhan Zhou, Qingzhuo Cui, Xinli Shi*, Cisplatin promotes the expression level of PD-L1 in the microenvironment of hepatocellular carcinoma through YAP1,Molecular and Cellular Biochemistry, 2020, 475(1), 79-91.通讯作者
25. 薛玉，李彩格，刘一玮，杨佳丽，张智琴，纪敬敏，于琨，石新丽*，基于非靶向代谢组学探讨YAP1改善马兜铃酸I诱导小鼠肝损伤的效应，中药新药与临床药理，2024，35（1）：46-55.
26. 高玉亭，郝立园，彭晴，国英琳，石新丽，基于转录组学分析双氢青蒿素干预肝癌细胞 HepG2215后的基因表达差异，中药新药与临床药理，2022，33（12）：1599-1605.
27. 李圣豪，郝立园，国英琳，彭晴，丁静茹，石新丽*，丹参水溶性组分SABP对小鼠肝癌免疫微环境的影响，肿瘤防治研究，2021，48（7）：694-698.
28. 李圣豪，石新丽*，原发性肝癌中PD-L1表达调控机制的研究，肿瘤防治研究，2021，48（11）：1052-1058.
29. 石新丽，疫情背景下的研究生“免疫学发展简史”章节线上教学设计，中国免疫学杂志，2020，36（18）：2241-2243.
30. 纪敬敏，石新丽*，基于网络药理学探讨藿香正气液干预新型冠状病毒感染的潜在靶点，重庆医学，2020，49(19):3145-3150.
著作：
1. 石新丽（编委）全国高等中医药教育（本科）国家卫生健康委员会“十四五”规划教材，《免疫学基础与病原生物学》（第3版），人民卫生出版社，2021年8月，编委
2. 曹东义（主编）、张培红（副主编）、王红霞（副主编）、姜俊峰（副主编）、石新丽（编委，第33位）“燕赵中医学术流派研究丛书” 河北科学技术出版社，2022年3月出版，编委
联系方式：0351-3179845
办公电话：0351-3179845
Email：sxlsunshine@sina.com
