罗寿青导师简介

个人简介:
罗寿青,特聘教授,北京协和医学院博士。先后在美国国立卫生研究院和英国剑桥大学工作,任博士后、研究员、高级研究员,后任英国普利茅斯大学教授,现任山西中医药大学特聘教授。他在生物化学及细胞和分子生物学领域具有深厚的造诣,研究聚焦于自噬和蛋白聚集体的调控及神经退行性疾病研究,迄今文章的总引用数超过2万次。
研究学科(领域):中医基础理论
研究方向:中西医结合基础研究
在研项目:
1.ALS-linked SQSTM1/p62 mutations and prolonged inflammatory toxicity(Luo/Apr24/2360-791), Motor Neurone Disease Association, 2024-10-至今,151万,主持。
2.Luo Laboratory research funding forHuntington's disease (GL110002-129),2022-12-至今,Anonymous Donor Research grant,74.7万,主持。
3.The caspase-6-p62 axis inAlzheimer’s disease (ARUK-ECRBF2023B-001),Alzheimer's Research UK,2024-02-至今,24.7万,主持。
4.Alleviating futileautophagosome synthesis (FAS) for neuroprotection in Huntington’s DiseaseUK(105251-133),Peninsula Medical Foundation,2021-12-至今,67.7万,主持
5.Lowering autophagosomal overload tomitigate synucleinopathies (PGL21/10002),Rosetrees Trust,2022-01-至今,91.2万,主持
近期代表性论著:
1.BarrowER, Valionyte E, Baxter CR, Yang Y, Herath S, O’Connell WA, Lopatecka J, Strachan A, Woznica W, Stephenson HN, Fejer G, Sharma V, Lu B,Luo S*. Discovery of SQSTM1/p62-dependent P-bodies that regulate NLRP3 inflammasome.Cell Reports,2024, 43(3):113935. doi: 10.1016/j.celrep.2024.
2.Pan Y, Lu J, Feng X, Lu S, Yang Y, Yang G, Tan S, Wang L, Li P,Luo S*, Lu B*. The Gelation of Cytoplasmic CAG Repeat Expansion RNAs Suppresses Global Protein Translation.Nature Chemical Biology, 2023, 19(11):1372-1383,doi:10.1038/s41589-023-01384-5. *: Co-corresponding author.
3.Yang Y, Willis TL, Button RW, Strang CJ, Fu Y, Wen X, Grayson PRC, Evans T, Sipthorpe RJ, Roberts SL, Hu B, Zhang J, Lu B,Luo S*. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response.Nature Communications, 2019,10(1):3759,doi.org/10.1038/s41467-019-11671-2.
4.Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C,Luo S*, et al. Allele-selective Degradation of Mutant HTT via Autophagy by HTT-LC3 Linker Compounds.Nature,2019, 575(7781):203-209.
5.Valionyte E, Yang Y, Griffiths SA, Bone AT, Barrow ER, Sharma V, Lu B,Luo S*. The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner.Cell Death and Differentiation,2022,29(6):1211-1227.