张钊导师简介

个人简介:
张钊,女,1986年1月出生,毕业于中国医学科学院药物研究所。博士,副研究员,山西中医药大学硕士生导师。先后主持科研项目8项,发表论文70余篇,其中SCI论文60篇,出版专著10余部。
研究学科(领域):中医基础理论
研究方向:中医脑病学
在研项目:
龙血竭活性成分抑制CKLF1/CCR5诱导的NETs促进脑卒中后血运重塑及功能修复(82374060),国家自然科学基金面上项目,2024.01-2027.12,62.4万,主持。
国家自然科学基金联合基金重点支持项目,U21A20410,黄芪调控神经血管偶联在补阳还五汤改善慢性脑缺血中的作用确证与机制探索,2022. 01-2025.12,130万,合作单位负责人。
广西中药质量标准研究重点实验室开放课题(桂中重开2202402),龙血竭活性成分龙血素B对卒中后神经修复的作用及机制研究,2024.08-2026.07,8万,主持。
中国医学科学院医学与健康科技创新工程,重大生命健康问题共性机理研究方向,多风险因素影响脑稳态的机理及干预研究(2021-I2M-1-020),2021.10-2025.12,200万,参与。
代表性成果:
Wang SS, Peng Y, Fan PL, Ye JR, Ma WY, Wu QL, Wang HY, Tian YJ, He WB, Yan X, Zhang Z*, Chu SF*, Chen NH*. Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle. Acta Pharmacol Sin. 2024 Sep 3. doi: 10.1038/s41401-024-01374-w. Epub ahead of print. PMID: 39227736.
He JQ, Yuan RL, Jiang YT, Peng Y, Ye JR, Wang SS, Li LQ, Ruan Y, Li PY, Yan X, He WB, Li G, Chu SF*, Zhang Z*, Chen NH*. Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration. Acta Pharmacol Sin. 2024 Aug 7. doi: 10.1038/s41401-024-01352-2. Epub ahead of print. PMID: 39112771.
Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S*, Zhang Z*, Chen N*. CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction. Autophagy. 2023 Oct 31.
Peng Y, Ye JR, Wang SS, He WB, Feng ZP, Sun HS, Chu SF*, Zhang Z*, Chen NH*. A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson's disease. Cell Death Dis. 2023 Sep 6;14(9):594.
Ma WY, Wu QL, Wang SS, Wang HY, Ye JR, Sun HS, Feng ZP, He WB, Chu SF*, Zhang Z*, Chen NH*. A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke. J Neuroinflammation. 2023 Apr 25;20(1):97.
Wu QL, Cui LY, Ma WY, Wang SS, Zhang Z, Feng ZP, Sun HS, Chu SF*, He WB*, Chen NH*. A novel small-molecular CCR5 antagonist promotes neural repair after stroke. Acta Pharmacol Sin. 2023 Oct;44(10):1935-1947.
Zhu J, Chu SF, Peng Y, Liu DD, Chen C, Jian WX, Sun HS, Feng ZP, Zhang Z*, Chen NH*. Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice. Acta Pharmacol Sin. 2022 April;43(4):797–810.
Dong YX, Chu SF, Wang SS, Tian YJ, He WB, Du YS, Wang ZZ, Yan X, Zhang Z*, Chen NH*. Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response. Acta Pharmacol Sin. 2022 Mar;43(3):563-576.
联系方式:15101050658
办公电话:010-63165180
Email:zhangzhao@imm.ac.cn