陈乃宏导师简介

个人简介：

陈乃宏，男，1961年1月出生，毕业于日本国立琦玉大学。博士，研究员，山西中医药大学硕士生导师。先后主持科研项目60余项，发表论文200余篇，其中中文核心（或SCI）论文 180余篇，出版专著10余部。

研究学科（领域）：中药药理学

研究方向：中药神经精神药理学

在研项目：

1.      以CKLF1为新型药物靶标的发现及其抗缺血性损伤的系统性药理学研究（81730096），国家自然科学基金重点项目，2018.01-2022.12，290万元，主持。

2.      基于神经炎症失调的抑郁症治疗新靶标星型胶质细胞缝隙连接功能的确证与创新药物发现（82130109），国家自然科学基金重点项目，2022.01-2026.12，290万元，主持。

3.      脑疾病干预治疗策略的研发（2021-I2M-1-020）,中国医学科学院医学与健康科技创新工程, 2021.10-2025.12, 600万元，主持。

代表性成果：

1.      Liu YJ^#, Chu SF, Hu YM, Yang SW, Li X, Zheng QL, Ai QD, Ren SY, Wang HQ, Gong LM, Xu X, Chen NH^*. Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes. Cell Mol Neurobiol. 2021;41(4):687-704.

2.      Chu SF^#, Zhang Z^#, Zhou X, He WB, Yang B, Cui LY, He HY, Wang ZZ, Chen NH^*. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. Acta Pharmacol Sin. 2021;42(6):848-860.

3.      Li FF^#, Zhou X, Chu SF, Chen NH^*. Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury via MAPK pathway. Cytokine. 2021; 141:155429.

4.      Wang HY^#, Ye JR, Cui LY, Chu SF^*, Chen NH^*. Regulatory T cells in ischemic stroke. Acta Pharmacol Sin. 2021 Mar 26. doi: 10.1038/s41401-021-00641-4. Online ahead of print.

5.      Wang HQ^#, Wang ZZ^*, Chen NH^*. The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates. Pharmacol Res. 2021; 167:105542.

6.      Zhang YN^#, Zhang XL, Liu N, Ren SY, Xia CY, Yang X, Lou YX, Wang HQ, Zhang NN, Yan X, Zhang Z, Zhang Y, Wang ZZ*, Chen NH*. Comparative proteomic characterization of ventral hippocampus in susceptible and resilient rats subjected to chronic unpredictable stress. Frontiers in Neuroscience, 2021;15:675430.

7.      Wang HQ^#, Yang SW, Gao Y, Liu YJ, Li X, Ai QD, Lin MY, Yang YT, Zeng Q, Zhang Y, Wang ZZ^*, Chen NH^*. Novel antidepressant mechanism of ginsenoside Rg1: Regulating biosynthesis and degradation of connexin 43. J Ethnopharmacol. 2021; 278:114212.

8.      Ren SY^#, Zhang YN, Wang MJ, Wen BR, Xia CY, Li X, Wang HQ, Zhang RP, Zhang Y, Wang ZZ^*, Chen NH^*. Hair growth predicts a depression-like phenotype in rats as a mirror of stress traceability. Neurochem Int. 2021; 148:105110.

9.      Zhu J^#, Chu SF, Peng Y, Liu DD, Chen C, Jian WX, Sun HS, Feng ZP, Zhang Z^*, Chen NH^*. Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice. Acta Pharmacol Sin. 2021 Jul 5. doi: 10.1038/s41401-021-00694-5.

10.  Dong YX^#, Chu SF, Wang SS, Tian YJ, He WB, Du YS, Wang ZZ, Yan X, Zhang Z^*, Chen NH^*. Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response. Acta Pharmacol Sin. 2021 Jun 8. doi: 10.1038/s41401-021-00696-3.

11.  Zheng QL^#, Zhu HY, Xu X, Chu SF^*, Cui LY, Dong YX, Liu YJ, Zhan JH, Wang ZZ, Chen NH^*. Korean red ginseng alleviated depressive disorder by improving astrocyte gap junction function. J Ethnopharmacol. 2021; 281:114466.

12.  Zhou X^#, Zhang YN, Li FF, Zhang Z, Cui LY, He HY, Yan X, He WB, Sun HS, Feng ZP, Chu SF^*, Chen NH^*. Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke. Acta Pharmacol Sin. 2021 Aug 12. doi: 10.1038/s41401-021-00746-w.

13.  Wu QL^#, Gao Y, Li JT, Ma WY, Chen NH^*. The Role of AMPARs Composition and Trafficking in Synaptic Plasticity and Diseases. Cell Mol Neurobiol. 2021 Aug 26. doi: 10.1007/s10571-021-01141-z.

14.  Ye JR^#, Wang HY, Cui LY, Chu SF^*, Chen NH^*. The progress of chemokines and chemokine receptors in autism spectrum disorders. Brain Res Bull. 2021; 174:268-280.

15.  Yang X^#, Chu SF, Wang ZZ, Li FF, Yuan YH, Chen NH^*. Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways in the striatum. Acta Pharmacol Sin. 2021 Sep;42(9):1409-1421.

16.  Han QW^#, Yuan YH^*, Chen NH^*. The Therapeutic Role of Cannabinoid Receptors and Its Agonists or Antagonists in Parkinson's Disease. Prog Neuropsychopharmacol Biol Psychiatry. 2020; 96:109745.

17.  Liu N^#, Wang ZZ, Zhao M, Zhang Y, Chen NH^*. Role of Non-Coding RNA in the Pathogenesis of Depression. Gene. 2020; 735:144276.

18.  Mou Z^#, Yuan YH, Zhang Z, Song LK, Chen NH^*. Endoplasmic Reticulum Stress, an Important Factor in the Development of Parkinson's Disease. Toxicol Lett. 2020;324:20-29.

19.  Cui LY^#, Chu SF, Chen NH^*. The role of chemokines and chemokine receptors in multiple sclerosis. Int Immunopharmacol. 2020; 83:106314.

20.  Wang SS^#, Bi HZ, Chu SF, Dong YX, He WB, Tian YJ, Zang YD, Zhang DM, Zhang Z^*, Chen NH^*. CZ-7, a New Derivative of Claulansine F, Promotes Remyelination Induced by Cuprizone by Enhancing Myelin Debris Clearance. Brain Res Bull. 2020;159:67-78.

21.  Chen C^#, Chu SF^*, Ai QD, Zhang Z, Chen NH^*. CKLF1/CCR5 Axis Is Involved in Neutrophils Migration of Rats With Transient Cerebral Ischemia. Int Immunopharmacol. 2020; 85:106577.

22.  Xia CY^#, Wang ZZ^#, Wang HQ, Ren SY, Lou YX, Jin C, Qu TG, Feng ST, Zhang Y, Chu SF, Chen NH^*. Connexin 43: A Novel Ginsenoside Rg1-sensitive Target in a Rat Model of Depression. Neuropharmacology. 2020; 170:108041.

23.  Ren SY^#, Wang ZZ, Zhang Y, Chen NH^*. Potential Application of Endocannabinoid System Agents in Neuropsychiatric and Neurodegenerative Diseases-Focusing on FAAH/MAGL Inhibitors. Acta Pharmacol Sin. 2020 Oct;41(10):1263-1271.

24.  Jian WX^#, Zhang Z, Zhan JH, Chu SF, Peng Y, Zhao M, Wang Q, Chen NH^*. Donepezil Attenuates Vascular Dementia in Rats Through Increasing BDNF Induced by Reducing HDAC6 Nuclear Translocation. Acta Pharmacol Sin. 2020 May;41(5):588-598.

25.  Yang SW^#, Chu SF, Ai QD, Zhang Z, Gao Y, Lin MY, Liu YJ, Hu YM, Li X, Peng Y, Pan YW, He QH, Chen NH^*. Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF-κB and Nrf2/HO-1 signaling pathways. Int Immunopharmacol. 2020; 85:106629.

26.  Chu SF^#, Niu ZQ, Guo QX, Bi HZ, Li XY, Li FF, Zhang Z, He WB, Cao P, Chen NH^*, Sun XY^*. Combination of monoammonium glycyrrhizinate and cysteine hydrochloride ameliorated lipopolysaccharide/galactosamine-induced acute liver injury through Nrf2/ARE pathway. Eur J Pharmacol. 2020; 882:173258.

27.  Lou YX^#, Wang ZZ^#*, Xia CY, Mou Z, Ren Q, Liu DD, Zhang X, Chen NH^*. The protective effect of ginsenoside Rg1 on depression may benefit from the gap junction function in hippocampal astrocytes. Eur J Pharmacol. 2020; 882:173309.

28.  Li X^#, Chu SF, Lin MY, Gao Y, Liu YJ, Yang SW, Zhou X, Zhang YN, Hu YM, Wang HQ, Chen NH^*. Anticancer property of ginsenoside Rh2 from ginseng. Eur J Med Chem. 2020; 203:112627.

29.  Zhou X^#, Chu SF, Liu JQ, Liu YJ, Xu X, He WB, Zhang W, Chen NH^*. Traditional Chinese Medicine Prevented Brain Injury via Regulating the Activation of Microglia After Ischemic Stroke. Progress in Biochemistry and Biophysics. 2020, 47(8): 700-711.

30. 药理学实验操作教程（全视频展示）,中国协和医科大学出版社，360千字,2021.09

联系方式：

办公电话：010-63165177

Email：chennh@imm.ac.cn