李亚峰导师简介
个人简介:
李亚峰,男,1981年12月出生,武汉大学医学博士,留美博士后。山西省人民医院肾内科主任医师,博士生导师。山西省人民医院中心实验室主任,肾脏病山西省重点实验室副主任,山西医科大学微生态研究院院长。先后主持科研项目13项,发表论文50余篇,其中以第一/通讯作者发表SCI论文18篇。获批专利20项,其中发明专利8项,实用新型专利12项。
研究学科(领域):内科学
研究方向:黏膜屏障损伤参与IgA肾病的机制研究
在研项目:
1. 肠道菌群通过CASP-1/IL-1β调节肠道通透性参与IgA肾病发病机制研究(82170716),国家自然科学基金面上项目,2022.01- 2025.12,55万元,主持。
2. GPR55介导溶血磷脂酰肌醇通过mtROS通路活化内皮细胞促进动脉粥样硬化机制研究(81870333),国家自然科学基金面上项目,2019.01-2022.12,57万元,主持。
3. 肾小球肾炎尿液N-磷酸化蛋白质组学研究(2020XM21),山西省卫健委“四个一批”重点攻关专项,2021.01-2023.01,15万元,主持。
4. NLRP3介导肠道菌群代谢物TMAO增加肠道通透性促进IgA在肾脏沉积的机制研究(2020-183),山西省回国留学人员科研资助项目,2020.09-2023.09,5万元,主持。
代表性成果:
以一作或通讯作者发表SCI论文:
1. Yasin Abdi Saed; Weiwei Xu; Hasnaa Yaigoub; Hasna Tirichen; Lili Guo; Li Cheng; Yafeng Li*; As Signals From the Kawasaki-Like Illness During the COVID-19 Pandemic: Is It Possible That the Incidence of IgA Nephropathy May Increase in the Future, Front. Med, 2021, 8:737692. (IF:5.093,通讯作者)
2. Chenxi Li; Manyun Qian; Qiaozhen Hong; Xiaohong Xin; Zichun Sun; Yafeng Li*; Bo Tang*; Bing Gu*; Rapid; quantitative;and high-sensitivity detection of anti-phospholipase A2 receptor antibodies using a novel CdSe/ZnS-based fluorescence immunosorbent assay, Sci Rep, 2021, 11(1):8778. (IF:4.371,共同通讯作者)
3. Yuan Li; Sheng-Xiao Zhang; Xu-Fang Yin; Ming-Xing Zhang; Jun Qiao; Xiao-Hong Xin; Min-Jing Chang; Chong Gao ; Yafeng Li*; Xiao-Feng Li*; The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis, J Immunol Res, 2021, 2021:6665563. (IF:4.814,共同通讯作者)
4. Jian Lu; Sonia Samuel; Yasin Abdi Saed; Rongshan Li; Yafeng Li*; A case of postpartum AKI: recurrent atypical hemolytic uremic syndrome; HELLP syndrome or paroxysmal nocturnal hemoglobinuria? Lessons for the clinical nephrologist, J Nephrol, 2021. (IF:3.902,通讯作者)
5. Hasna Tirichen; Hasnaa Yaigoub; Weiwei Xu; Changxin Wu; Rongshan Li; Yafeng Li*; Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress, Front Physiol, 2021, 12:627837. (IF:4.561,通讯作者)
6. Yuehong Ma; Ling Fang; Rui Zhang; Peng Zhao; Yafeng Li*; Rongshan Li*. Cyclophosphamide Attenuates Fibrosis in Lupus Nephritis by Regulating Mesangial Cell Cycle Progression, Dis Markers, 2021, 2021:3803601. (IF:3.430,共同通讯作者)
7. Sheng-Xiao Zhang#; Jia Wang#; Jun-Wei Chen; Ming-Xing Zhang; Yi-Fan Zhang; Fang-Yuan Hu; Zhi-Qin Lv; Chong Gao; Yafeng Li* ; Xiao-Feng Li *; The level of peripheral regulatory T cells is linked to changes in gut commensal microflora in patients with systemic lupus erythematosus, Ann Rheum Dis, 2021, 80(11):e177. (IF:19.101,共同通讯作者)
8. Yafeng Li; Gayani Nanayakkara; Yu Sun; Xinyuan Li; Luqiao Wang; Ramon Cueto; Ying Shao; Hangfei Fu; Candice Johnson; Jiali Cheng; Xiongwen Chen; Wenhui Hu; Jun Yu; Eric T. Choi; Hong Wang; Xiao-feng Yang*; Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-; IL-18- and sirtuin-1-independent pathways, Journal of Hematology & Oncology , 2017, 10(1):40. (IF:17.388,第一作者)
9. Yafeng Li; Xiao Huang; Xinyuan Li; Ren Gong; Ying Yin; Jun Nelson; Erhe Gao; Hongyu Zhang; Nicholas E Hoffman; Steven R Houser; Muniswamy Madesh; Douglas G Tilley; Eric T Choi; Xiaohua Jiang; Cong-Xin Huang; Hong Wang; Xiao-Feng Yang*; Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair, Frontiers in Bioscience, 2016, 21:178-191. (IF:4.009,第一作者)
10. Yafeng Li; Rong-Shan Li; Sonia B Samuel; Ramon Cueto; Xin-Yuan Li; Hong Wang; Xiao-Feng Yang*; Lysophospholipids and their G protein-coupled receptors in atherosclerosis, Frontiers in Bioscience, 2015,21(1):70-88. (IF:4.009,第一作者)
11. Yafeng Li; Li-Na Ren; Geng Guo; Lee Anne Cannella; Valeria Chernaya; Sonia Samuel; Su-Xuan Liu; Hong Wang; Xiao-Feng Yang*; Endothelial progenitor cells in ischemic stroke: An exploration from hypothesis to therapy, Journal of Hematology & Oncology, 2015, 8(1):33. (IF:17.388,第一作者)
12. Jie Zheng; Yuzhen Gao; Yuejuan Jing; Xiaoshuang Zhou; Yuanyuan Shi; Yanhong Li; Lihua Wang; Ruiying Wang; Maolian Li; Chuanshi Xiao; Yafeng Li*; Rongshan Li*; Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic urban Chinese population: a cross-section study, Frontiers of Medicine , 2014, 8(4). (IF:4.591,共同通讯作者)
13. Yafeng Li; Ying Jing; Jielu Hao; Nathan C Frankfort; Xiaoshuang Zhou; Bing Shen; Xinyan Liu; Lihua Wang; Rongshan Li*; MicroRNA-21 in the pathogenesis of acute kidney injury, Protein & Cell, 2013, 4(11):813-819. (IF:14.873,第一作者)
14. Yafeng Li; Jing Luo; Qian Li; Yue-Juan Jing; Rui-Ying Wang; Rong-Shan Li*; A New Simple Model for Prediction of Hospital Mortality in Patients with Intracerebral Hemorrhage, CNS Neuroscience & Therapeutics, 2012, 18(6):482-486. (IF:5.240,第一作者)
15. Yafeng Li; Xiao-Ming Zhu; Fan Liu; Chuan-Shi Xiao; Yun-Fei Bian; Hong Li; Jun Cai; Rong-Shan Li; Xin-Chun Yang*; Angiotensin-Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism and ACE Inhibitor-Related Cough: A Meta-Analysis, PLoS ONE , 2012, 7(6):e37396. (IF:3.242,第一作者)
16. Yafeng Li; Chuan-Shi Xiao; Ru-Tai Hui*: Calcium sulfide (CaS); a donor of hydrogen sulfide (H2S): A new antihypertensive drug?, Medical Hypotheses, 2009, 73(3):445-447. (IF:4.533,第一作者)
中华及核心(第一/通讯作者)期刊论文:
1. 和晓莹; 秦智琦; 段琦; 赵欣; 龚豪; 李亚峰*; 氧化低密度脂蛋白激活PYHIN1/Caspase 1炎症复合体信号通路增强主动脉内皮细胞黏附的机制研究[J]. 中国分子心脏病学杂志, 2021, 21(05):4248-4252.(通讯作者)
2. 董娅芳; 韩慧敏; 李亚峰*; 郭丽丽*; 组氨酸激酶和组氨酸磷酸酶在肿瘤中的作用[J].中国肺癌杂志, 2021, 24(09):646-652.(共同通讯作者)
3. 卢健; 郭丽丽; 薛福平; 张婷婷; 李媛; 王艳勤; 李爱中; 李亚峰*; 李荣山; NLRP3炎症体信号通路在促进慢性肾脏病相关性血管新生内膜增生中的作用[J]. 中华肾脏病杂志, 2021, 37(03):198-208. (通讯作者)
4. 张厦栋; 辛晓红; 常敏静; 段琦; 王倩; 李亚峰*.动脉性肺动脉高压相关基因的生物信息学分析[J]. 中国分子心脏病学杂志, 2020, 20(01):3255-3263. (通讯作者)
奖励:
1. 李亚峰(1/6),利用“中和抗体滴度检测”,指导新冠疫苗上市前评价,山西省总工会,共青团山西省委员会,山西省科学技术协会,山西省“五小”创新大赛,一等奖,2021。
2. 李亚峰(4/8),内源性小分子肽 intermedin 和 irisin 治疗肾小管缺氧-复氧损伤的实验研究,山西省科技厅,山西省科学技术进步奖(自然科学类),二等奖,2021。
3. 李亚峰(4/6),FRAT1基因对人脑胶质细胞瘤生物学特性的影响及临床应用,山西省科技厅,山西省科技进步奖(自然科学类),三等奖,2013。
专利:
发明专利:
1.一种Alport综合征的通用基因检测文库的构建方法及其试剂盒(ZL202010657187.8)
2.一种人源抗新型冠状病毒(SARS-CoV-2)的中和活性单克隆抗体(ZL202011265546.1)
3. 一种人源抗新型冠状病毒的中和活性单克隆抗体(ZL202011366459.5)
4. 提取及纯化桦褐孔菌多酚的方法(ZL201910381326.6)
5. 一种高效提取、纯化桦褐孔菌多糖的方法(ZL201910381327.0)
6. 提取分离纯化桦褐孔菌醇的方法(ZL202011213459.1)
7. 一种从桦褐孔菌中提取分离栓菌酸的方法(ZL202011212181.6)
8. 一种筛选对肠道微生态具有促进作用的提取物方法及将其应用于靶向筛选益生菌的应用(ZL202110770319.2)
实用新型专利:
1. 玻璃微珠定量取样装置(ZL201920405441.8)
2. 一种新型粪便采集器(ZL201920400403.3)
3. 一种EP管开盖器(ZL201920533749.0)
4. 一种彩色标识微孔板(ZL201920533753.7)
5. 一种实验室用开管手套(ZL201920533804.6)
6. 一种封口膜自动封口装置(ZL201920173533.8)
7.一种唾液流量测定装置(ZL201920511689.2)
8. 一种乳腺术后固定文胸(ZL201920167014.0)
9. 一种用于眼三项检测的试(ZL201920405283.6)
10. 一种方便开盖的EP管(ZL201920533802.7)
11. 一种具有存储装置的加样枪(ZL201920533808.4)
12. 一种稳定且便于移动调节的连排枪头(ZL202020388085.6)
联系方式:
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